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Labisia Pumila Herbal Extract
  • Identified by Dr Wan Nazaimoon Wan Mahmud, head of the Cardiovascular, Diabetic & Nutrition Research Center at the Institute for Medical Research, Malaysia as the most powerful source of phytoestrogens
  • Exhibit the pharmacokinetics of Selective Estrogen Receptors Modulators in clinical stuides
  • Had been used traditionally by native Malays in post-partum recovery
  • Labisia Pumila extracts at nano-size penetrate vaginal cell's membrane and stimulate the proliferation of vaginal tissues, leading to the tightening effect from the increased vaginal cell mass
  • Postpartum Herb Investigated

    Source: Medical Tribune
    Publisher: MediMedia Asia
    01 November 2002

    MALAYSIA-Local researchers are studying a herb traditionally used by women during their postpartum confinement period.

    According to Dr Wan Nazaimoon Wan Mahmud, head of the Cardiovascular, Diabetic & Nutrition Research Center at the Institute for Medical Research, Labisia pumila var alata (Kacip Fatimah) is being studied in an Intensified Research in Priority Areas (IRPA) project under the National Biotechnology Directorate.

    Dr Wan Nazaimoon explained that L pumila was traditionally consumed in the form of capsules or drinks. The herbal concoction has been claimed to facilitate the postpartum contraction of the uterine and vaginal wall.

    The IMR study aims to determine whether L pumila has estrogenic and/or androgenic activity that can be correlated to its traditional indications.

    In addition, they intend to find out if the activity is due to phytoestrogens or SERMs (selected estrogen receptor modulators), or due to a single compound or more, or is a synergistic effect.

    Dr Wan Nazaimoon outlined the research strategy, saying the team had decided to produce an extract using the traditional method of slow boiling the herb to obtain a water extract. The extract was then spray-dried and used in animal studies.

    The dose-response effect of the extract on the reproductive hormones of female rats has been completed, and the optimum dose obtained. The equivalent dose for human trials will be calculated from these results.

    In the clinical trials to be carried out at Universiti Kebangsaan Malaysia (UKM) and Universiti Sains Malaysia (USM), the extract will be given as a herbal supplement to healthy women and their hormonal profile assessed. This data will be used for reference and standardization.

    The team has also completed studies on the cytotoxic and the proliferative effects of the extract on human cancer cells - breast, liver and cervix - with no adverse effect observed.

    Researchers from Universiti Malaysia Sabah and Forest Research Institute Malaysia are jointly working on this study.

    The Oestrogenis and Cytotoxic Effects of the Extracts of Labisia pumila var. alata and Labisia pumila var. pumila In Vitro. JAM1A A. JAMAL, HOUGHTON P. J., MILLIGAN S. R. & IBRAHIM JANTAN. Jurnal Sains Kesihatan Malaysia 1 Julai/Julv 2003

    Abstract

  • Aqueous, acid hydrolysed and ethanolic extracts of the roots and leaves of Labisia pumila var. alata and Labisia pumila var. alata and Labisia pumila var. pumila were investigated for their oestrogenic and cytotoxic effects using Ishikawa cell line by performing an in vitro Ishikawa alkaline phosphatase assay and an in vitro protein assay, respectively.
  • Among them, only the ethanol extract of the root of L. pumila var. alata exhibited a weak oestrogenic activity at 10-50 mg/ml.
  • The samples that exhibited significant cytotoxic effect were the ethanol extract of the roots of L. pumila var. alata (IC50 433 mg/ml), and the aqueous extracts of the roots of L. pumila var. alata (IC50 433 mg/ml) and the leaves of L. pumila var. pumila (IC50 458 mg/ml).
  • Key words: Labisia pumila, ethanol extract, oestrogenic activity, cytotoxic effect



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